February | 28, 2017 :: Research Shows This One Plant (KARELA FRUIT) Can Kill Cancer Cells & Treat Diabetes
Bitter melon (Karela) is a fruit that grows abundantly in Asia, Africa and the Caribbean. Traditionally it has been used to treat diabetes and other more mild diseases or illnesses.
More recently, bitter melon juice was shown to kill pancreatic cancer cells in vitro and in mice in a study done by the University of Colorado. Considering the results were seen in both in vitro and in vivo tests, the effectiveness of bitter melon juice in treating pancreatic cancer, and potentially other cancers, at a clinical level are promising.
“IHC analyses of MiaPaCa-2 xenografts showed that BMJ(Bitter Melon Juice) also inhibits proliferation, induces apoptosis and activates AMPK (adenosine monophosphate-activated protein kinase) in vivo. Overall, BMJ exerts strong anticancer efficacy against human pancreatic carcinoma cells, both in vitro and in vivo, suggesting its clinical usefulness.”
Many cancerous tumors have insulin receptors which move glucose to cancer cells helping them to grow and divide. Studies have shown that insulin encourages pancreatic cancer cells to grow in a dose dependant manner, since bitter melon has been shown to help regulate insulin levels, this could help prevent pancreatic cancer over the long-term.
The Colorado University study was led by Dr. Rajesh Agarwal. They examined effects of bitter melon on 4 different lines of pancreatic cancer cells (in vitro) and in mice. For the in vivo studies, mice were injected with pancreatic tumor cells and were randomly divided into one of two groups. One group of mice received water, which was the control group, and the other group was given bitter melon juice for six weeks.
Researchers studied the tumors at the end of the study and results showed that bitter melon juice not only inhibited cancer cell proliferation but also induced apoptosis (programmed cell death). Compared to the control, tumor growth was inhibited by 60% in the treatment group and there were no signs of toxicity or negative effects on the body. With toxicity and negative effects being a huge role in traditional mainstream treatments, this was positive to see.
A number of clinical studies have been conducted to evaluate the efficacy of bitter melon for treating diabetes. Since it is believed that diabetes is a precursor for pancreatic cancer, researchers felt bitter melon could treat diabetes as well after seeing pancreatic cancer results.
As published by the study: “Bitter melon had a modest hypoglycemic effect and significantly reduced fructosamine levels from baseline among patients with type 2 diabetes who received 2,000 mg/day. However, the hypoglycemic effect of bitter melon was less than metformin 1,000 mg/day.”
Another study published in 2008 in the international journal Chemistry and Biology indicated that compounds in bitter melon improved glycemic control, helped cells uptake glucose and improved overall glucose tolerance. This study was done in mice and led to promising advancements in treating diabetes and obesity with bitter melon.
When it comes to bitter melon juice, the current research available is showing strong results for specific types of cancer cell destruction, diabetes treatment and potential prevention of pancreatic cancer Further research and clinical trials would be helpful to better understand how effective this plant can be and in what specific cases. It remains a very promising option that could be explored under the correct supervision.